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A multi-omics approach to investigate the inflammatory response to life course socioeconomic position


Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

Keywords: DNA methylation,gene expression,inflammation,life course epidemiology,protein,socioeconomic position

Author: Raphaële Castagné , Michelle Kelly-Irving , Vittorio Krogh , Domenico Palli , Salvatore Panico , Carlotta Sacerdote , Rosario Tumino , Dennie GAJ Hebels , Jos CS Kleinjans , Theo MCM de Kok , Panagiotis Georgiadis , Soterios A Kyrtopoulos , Roel Vermeulen , Silvia Stringhini , Paolo Vineis , Marc Chadeau-Hyam , Cyrille Delpierre
Journal: Epigenomics( IF:4.4 )   Time:2020-09-16
DOI:10.2217/epi-2019-0261    [Quote]
Link:     Article     PDF

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