Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.
DNA methylation,gene expression,inflammation,life course epidemiology,protein,socioeconomic position
Raphaële Castagné , Michelle Kelly-Irving , Vittorio Krogh , Domenico Palli , Salvatore Panico , Carlotta Sacerdote , Rosario Tumino , Dennie GAJ Hebels , Jos CS Kleinjans , Theo MCM de Kok , Panagiotis Georgiadis , Soterios A Kyrtopoulos , Roel Vermeulen , Silvia Stringhini , Paolo Vineis , Marc Chadeau-Hyam , Cyrille Delpierre
Journal: Epigenomics( IF：4.4 ) Time：2020-09-16
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