Open in APP

Hypertension Is Associated With an Earlier Age of Onset of Huntington's Disease


Background and Objective Hypertension (HTN) is associated with worsening clinical outcomes in neurodegenerative diseases. The relationship between HTN and the age of diagnosis (ADx) of Huntington's disease (HD) is not clear, however. This study sought to determine if the presence of HTN in adult patients with premanifest HD was associated with an earlier ADx compared with normotensive patients with HD. Methods Premanifest participants from Enroll‐HD were included if they had a cytosine‐adenine‐guanine greater than or equal to 36, baseline diagnostic confidence level less than 4, baseline total functional capacity score greater than 11, and baseline motor score less than 21. There were 3020 premanifest participants with HD, and 293 reported a diagnosis of HTN. HTN was transformed into a time‐dependent variable, and a Cox proportional hazard survival model determine if the presence of HTN affected the time to motor conversion. Baseline cytosine‐adenine‐guanine–age product score, cytosine‐adenine‐guanine repeat length, baseline age, sex, baseline body mass index, smoking history, and region were included as covariates. Results Participants with HTN had an increased annualized hazard of motor conversion compared to normotensive participants with HD (hazard ratio, 1.29; 95% confidence interval, 1.02–1.64; P = 0.034). Conclusions A previous study reported a protective effect of HTN in HD, but did not account for the fact that the prevalence of HTN increases with age. By controlling for this confounder, we more accurately outline the association between the ADx of HD to demonstrate that a diagnosis of HTN may be associated with an earlier ADx of HD. These results represent an association, however, and further investigation is warranted. © 2020 International Parkinson and Movement Disorder Society

Keywords: Enroll‐HD, Huntington's disease, hypertension, symptom onset

Author: Jordan L. Schultz, Lyndsay A. Harshman, Douglas R. Langbehn, Peg C. Nopoulos
Journal: Movement Disorders( IF:8.1 )   Time:2020-09-16
DOI:10.1002/mds.28062    [Quote]
Link:     Article     PDF

Comments    Read:4

Ftracker is a frontier tracker.
专业学术信息平台,免费并及时为您提供全球范围内各大期刊的最新学术信息。 “关键词内容订制”,”期刊浏览”,”数据库检索”,”期刊下载”,”评论讨论”。
Mobile App
IOS search "Ftracker" in AppStore
Ftracker学术犬: 970207982

文献求助群Ftracker: 698420805

新冠病毒交流Ftracker: 878107029

植物基因功能Ftracker: 556178713

©2020 Ftracker